The club was formed in 1955 by supporters of
Manchester City under the name City Supporters Rusholme. They played friendly matches before joining the
Rusholme Sunday League, remaining members until transferring to the Manchester Amateur Sunday League in 1966. Maine Road won the Division Two title at the first attempt, earning promotion to Division One, They went on to win Division One the following season and were promoted to the Premier Division. They retained the title for the next three seasons, before finishing as runners-up in 1986–87, after which the club moved up to Division Two of the
North West Counties League. Maine Road's first season in the North West Counties League saw them win the Manchester Premier Cup for a third time, beating
Irlam Town 1–0 in the final. Despite finishing as Division Two runners-up in
1988–89, the club were not promoted after failing to meet ground grading regulations. However, the
following season saw them win the Division Two title, earning promotion to Division One. They were Manchester Premier Cup finalists in 1998–99. Although the club were relegated at the end of the
2001–02 season, they were Division Two runners-up in
2003–04, and were promoted back to Division One, as well as reaching the final of the Manchester Premier Cup again. The club won the league's Challenge Cup in 2007–08, after which Division One was renamed the Premier Division. The club were Premier Division runners-up in
2013–14. However, they finished third-from-bottom of the Premier Division in
2017–18 season and were relegated to Division One South. At the end of the
2023–24 season the club were transferred to Division One North. ==Ground==