Freshman (1987) Harris took an offer at West Virginia, where coach
Don Nehlen was trying to rebuild the quarterback position. Nehlen set up a football camp for two-hand touch football and stated, "The kids couldn't touch him." Nehlen signed
Florida prep quarterback
Browning Nagle along with Harris and
redshirted them for the season. Harris and Nagle battled it out in spring practice and Harris eventually won the job, so Nagle transferred to
University of Louisville. Harris struggled at first, but when the fifth game came around at
East Carolina University, Harris stood out and ended West Virginia's season with a bid to the
Sun Bowl against
Oklahoma State University. West Virginia lost, but Harris rushed for over 100 yards. That season, Harris threw for 1,200 yards and 10 touchdowns on only 77 completions. Harris also rushed for 615 yards and 6 touchdowns.
Sophomore (1988) The following season, he directed West Virginia to the school's first-ever undefeated, untied regular season and a matchup against No. 1 ranked
Notre Dame in the
Fiesta Bowl for the national championship. In getting the Mountaineers to the Fiesta Bowl, Harris baffled opponents all season with his daring, unpredictable, wide-open style. Against
Boston College, Harris recorded a career-high 297 passing yards. Harris's dazzling play was never more evident than in West Virginia's 51–30 dismantling of long-time nemesis
Penn State. Harris outgained the entire Penn State team, 301 to 292, and produced the school's most exciting run ever in the first quarter of that game. That run and several more like it helped him finish fifth in the
Heisman Trophy race that year and earn ECAC player of the year honors. His season passing totals were 1,915 yards and 14 touchdowns, while he rushed for 610 yards and 6 touchdowns. He had the highest passing-efficiency rating of any college quarterback during the season, and totaled 2,348 total yards of offense and averaging 8.4 yards per touch. As the Mountaineers traveled to their first ever National Championship game, the Irish were favored. But on the third play of the game, Major Harris was hit and separated his shoulder. Harris stayed in the game, but didn't throw the ball often, scrambling instead. West Virginia never threatened Notre Dame's lead, and the Fighting Irish won, 34–21. Like 1988, Harris was again voted ECAC player of the year. That year, Harris led the Mountaineers to a
Gator Bowl game, but they lost to
Clemson, 27–7.
Legacy Harris established a WVU record with 7,334 total yards (ranks #7 through 2018 season), and became the first of just a handful of quarterbacks in Division I history to pass for more than 5,000 yards and rush for more than 2,000 yards in a career. His 2,161 rushing yards rank 17th (through 2021 season) on the school's all-time rushing list. Harris's longest pass of his career was 70 yards and his longest run was 75 yards. Harris was selected for the 2009
College Football Hall of Fame induction class. In 2021, West Virginia University retired Major's #9 jersey. ==Professional career==