Lesion

There is no designated classification or naming convention for lesions. Because lesions can occur anywhere in the body and their definition is so broad, the varieties of lesions are virtually endless. Generally, lesions may be classified by their patterns, sizes, locations, or causes. They can also be named after the person who discovered them. For example, Ghon lesions, which are found in the lungs of those with tuberculosis, are named after the lesion's discoverer, Anton Ghon. Cause and behavior If a lesion is caused by a tumor, it can be classified as malignant or benign after analysis of a biopsy. A benign lesion that is evolving into a malignant lesion is called "premalignant". Another type is an excitotoxic lesion, which can be caused by excitatory amino acids like kainic acid that kill neurons through overstimulation. Size and shape Lesion size may be specified as gross, meaning it is visible to the unaided eye, or histologic, meaning a microscope is needed to see it. A space-occupying lesion, as the name suggests, has a recognizable volume and may impinge on nearby structures, whereas a non space-occupying lesion is simply a hole in the tissue, such as a small area of the brain that has turned to fluid following a stroke. Lesions may also be classified by the shape they form, as is the case with many ulcers, which can have a bullseye or 'target' appearance. A coin lesion seen in an X-ray has the appearance of a coin sitting on the patient's chest. == Research using lesions ==

Brain lesions may help researchers understand brain function. Research involving lesions relies on two assumptions: that brain damage can affect different aspects of cognition independently, and that a locally damaged brain functions identically to a normal brain in its "undamaged" parts. Sham lesion is the name given to a control procedure during a lesion experiment. In a sham lesion, an animal may be placed in a stereotaxic apparatus and electrodes inserted as in the experimental condition, but no current is passed, so damage to the tissue should be minimal. Research with humans Humans with brain lesions are often subjects of research with the goal of establishing the function of the area where their lesion occurred. A drawback to the use of human subjects is the difficulty in finding subjects who have a lesion to the area the researcher wishes to study. As such, transcranial magnetic stimulation is often used in cognition and neuroscience-related tests to imitate the effect. Research with animals Using animal subjects gives researchers the ability to study lesions in specific body parts, allowing them to quickly acquire a large group of subjects. An example of such a study is the lesioning of rat hippocampi to establish the role of the hippocampus in object recognition and object recency. ==Notable lesions==