Fofana transferred to
Alanyaspor in 2016, joining from the academy of
Stade Malien. Fofana made his professional debut for Alanyaspor in a 2–3 Süper Lig loss to
Çaykur Rizespor on 14 January 2017. On 12 August 2021, he moved to
Ligue 2 club
Amiens and signed a five-year contract. Fofana played his first match for Amiens on 14 August 2021 in a league fixture against
EA Guingamp. He started as a central defender, and his team won the match 2–0. Fofana scored his first goal for Amiens on 30 October 2022 in a Coupe de France match against
Chambly. Starting the match and serving as captain that day, he helped his team secure victory after a penalty shoot-out.
New England Revolution On 2 December 2024 New England Revolution signed Mamadou Fofana from French Ligue 2 side Amiens SC. Fofana joined the Revolution for a reported fee of €1.7 million. Trésarrieu also reported Fofana signed a three-year contract with the Revolution. The deal also includes a club option for 2028. He scored his first MLS goal (and second career goal) on 4 April 2026 in a 3-0 win over
CF Montréal. ==International career==