Scientific investigation into 'man flu' and its journalistic uptake have been
disorderly. Some researchers refute outright the existence of man flu, while one study has suggested substantial evidence for the phenomenon while nevertheless remaining inconclusive on the question of its ultimate existence. Moreover, other scientific studies focused on gender differences in immune responses in contexts either broader than or separate from the flu have been cited in public discussion as evidence of the existence of 'man flu'. One study, published in 2009, investigated the effects of the
bacterium Listeria monocytogenes on
genetically modified mice. While the study did not pertain to cold or flu viruses, but rather to a
bacterial disease, it gained widespread attention and was misinterpreted by various
media outlets, including
The Daily Telegraph, as supporting the existence of 'man flu' in humans. In a study published in the
Journal of Psychosomatic Research, researchers affiliated with the
University Of Innsbruck found that while women may recover from flu symptoms more quickly than men, a uniquely severe sensitivity to the flu on the part of men does not exist. Research on
influenza vaccination suggested that women may be more responsive to vaccination than men, experiencing more local (
skin) and systemic (bodywide) reactions, and exhibiting a better
antibody response.
Testosterone levels in men were found to potentially play a role in their response to influenza vaccination, with men having the highest levels tending to show a lower antibody response. Since flu symptoms are largely attributed to the body's immune reaction, a lessened immune response in women may translate to milder symptoms. Despite such findings, this
BMJ article, in keeping with the a humorous tone of the journal's Christmas edition, is not intended to imply the existence of man flu. According to researchers at the
University of Cambridge, evolutionary factors may have led women to develop more rigorous
immune systems than men due to differing
reproductive strategies. In addition, a 2011 study conducted at the
University of Queensland suggests that
female hormones, such as
oestrogens, aid pre-menopausal women in fighting infections, but the protection is lost after
menopause. Research indicates that men are less inclined to seek medical attention when unwell and may underreport symptoms when they do. ==See also==