Mansi was inclined towards music and acting since her school days. She actively participated in school events and was a part of Channel V's pop star (Season 2) in 2003, where she was one of the 8 finalists alongside
Ayushman Khurrana. She made her acting debut in the serial
Kitni Mast Hai Zindagi in 2004, but gained popularity through Star One's
India Calling in 2005. She won Zee TV's singing reality show
Star Ya Rockstar. Manasi also appeared in Star Plus' prime-time show
Gulaal, and was also seen in shows like 9X's
Remote Control and Star One's
Laughter Ke Phatke. In April 2012, she appeared in the
Tamil romance film
Leelai alongside
Bollywood actor
Shiv Panditt. Manasi made her Hindi debut with
Yeh Kaisi Life, which premiered at the IFFI Festival in Goa. In 2019, she made her debut as a producer with the Gujarati web series
Do Not Disturb. In 2020, she made her debut in
Gujarati cinema with
Golkeri which was commercially successful. At the
70th National Film Awards, she won the
National Film Award for Best Actress in 2024 for her portrayal of Monghi in the film
Kutch Express, becoming the first Gujarati actress to receive this honor. Her next horror comedy film
Jhamkudi (2024) was a commercial success. ==Television==