PR 251 begins in the
Municipality of Two Borders at an intersection with
PR 256, north of the
Antler-Lyleton Border Crossing. It heads east through rural areas for several kilometres, passing through the
Lyleton community along Railway Avenue before joining
Provincial Trunk Highway 83 (PTH 83) in a short
concurrency (overlap). The highway now crosses the
Antler River and travels past the
Linear Mounds National Historic Site before passing through the hamlet of
Coulter and crossing the
Souris River. ==Major intersections==