The route begins by straddling the
Saskatchewan border going north, before curving eastward into Manitoba. The route continues west as
Saskatchewan Highway 361. The road is unpaved for its first or so before becoming paved just west of Tilston. PR 345 traverses mainly rural areas between the Saskatchewan province line and
PTH 21, while traversing the towns of
Tilston,
Broomhill,
Bede,
Bernice, and
Lauder. ==Major intersections==