PR 428 begins in the city of
Winkler at an intersection between
PTH 14 (
Boundary Commission Trail west) and the north end of
PTH 32 (1st Street /
Boundary Commission Trail east), located in the middle of a major business district just across the street from Southland Mall. It heads north through neighbourhoods to leave Winkler and enter the
Rural Municipality of Stanley, travelling through
Rosebrook before heading due north through rural farmland. The highway crosses several creeks as it enters the
Rural Municipality of Roland, continuing north through farmland for several more kilometres before coming to an end at an intersection with
PTH 23 just outside the town of
Roland. Excluding at the intersection between PTH 14 and PTH 32, which is a divided four-lane for a short distance, the entire length of PR 428 is a paved two-lane highway. ==Major intersections==