Youth football and early career Akanji began his youth career with the local club in
Wiesendangen. In May 2007, Akanji changed clubs and was a youth-team player for
FC Winterthur, featuring for their under-18 team and later with their second team. In the
2014–15 Challenge League, he became a regular starter for Winterthur, having played two games for them during the second half of the previous season.
FC Basel On 15 April 2015, it was announced that Akanji would be transferred to
FC Basel for the
2015–16 Swiss Super League season. He made his
Swiss Super League debut on 26 September 2015 being substituted in against
FC Lugano. Under manager
Urs Fischer, Akanji won the
Swiss Super League championship at the end of the
2015–16 Super League season. Basel then won the
2016–17 Swiss Super League and
2016–17 Swiss Cup double, making it the sixth time the club had achieved this feat in its history. As Swiss Champions, Basel qualified for the
2017–18 UEFA Champions League and started in the
group stage. Akanji played the full 90 minutes in all six games and helped the team finish second in its group, thus qualifying for the knockout phase.
Borussia Dortmund Akanji signed for
Borussia Dortmund on 15 January 2018 during the winter transfer window for a reported fee of €18 million He signed a four-and-a-half-year contract dated until June 2022. On 2 February, Akanji made his BVB debut as an 87th minute substitute for
André Schürrle in a 3–2 win at
1. FC Köln. On 27 September 2018, Akanji scored his first goal for the club and his first
Bundesliga goal in a 7–0 victory over
1. FC Nürnberg. Akanji was widely criticised for his costly errors during Dortmund's failed challenge to
Bayern Munich during the
2019–20 season. Akanji was one of the main players singled out as a weak link in the team. Akanji played the full 90 minutes as Dortmund beat
RB Leipzig 4–1 in the
2021 DFB-Pokal Final at the
Berlin Olympiastadion on 13 May 2021.
Manchester City 2022–23 season On 1 September 2022, Akanji joined
Premier League champions
Manchester City, signing a contract until 2027 for a reported fee of £15 million. He made his debut for City five days later, starting in a 4–0 away win over
Sevilla in the
Champions League group stage. He made his Premier League debut on 17 September, starting in a 3–0 away win over
Wolverhampton Wanderers. He was voted the club's Player of the Month for October. On 17 May 2023, he scored his first goal for the club, which was also his first in the Champions League, with a header deflected by
Éder Militão in a 4–0 home win over
Real Madrid in the semi-final second leg. During the
2022–23 Premier League, Akanji played more minutes than any other Manchester City defender.
2023–24 season On 21 October 2023, Akanji received his first red card for Manchester City in a 2–1 win over
Brighton & Hove Albion in the
Premier League. On 25 October, he scored his first goal of
the season in a 3–1 win over
BSC Young Boys in the
Champions League. He scored his first Premier League goal in a 6–1 win over
Bournemouth on 4 November and, on 12 November, scored in a third consecutive match as City drew 4–4 with
Chelsea at
Stamford Bridge.
2024–25 season On 10 August 2024, Akanji scored the winning penalty as Manchester City defeated
Manchester United 7–6 on penalties to win the
2024 FA Community Shield after a 1–1 draw in regular time.
Loan to Inter Milan On 2 September 2025, Akanji joined
Serie A side
Inter Milan on a season-long loan. ==International career==