Manuel Mamikonian was a 4th-century Armenian military commander and nobleman of the Mamikonian dynasty. He became the de facto leader of Armenia after driving the Arsacid king Varazdat out of the country and placing two young Arsacid princes, Arshak and Vagharshak, on the throne. He held the title of sparapet (commander-in-chief), which was the hereditary right of the Mamikonian family.