Some details of his early life remain obscure. He was born into a
Creole of Color family of Spanish, French and African descent. One of his ancestors was an officer of the free black regiment which fought in the
Battle of New Orleans. At the turn of the century, Perez became a member of the
Onward Brass Band, leading it from 1903 to 1930. Later, Perez went north to
Chicago in 1915, playing with
Charles Elgar's Creole Orchestra at the Arsonia Cafe and also with the Arthur Sims Band. Although Elgar and his Creole Orchestra recorded a few sides (albums) during this period, Perez is not heard on any of these early recordings. Returning to the Crescent City in the 1920s, he played in the District (
Storyville), on
steamboat excursions with
Fate Marable, and in parades with the Maple Leaf Orchestra. Perez suffered a stroke in 1930. During this period, he worked with his brother, who owned a moving company, while he ran the used furniture store.
Sidney Bechet said of him in the early 1940s: I was down in New Orleans and I saw Manuel before he died. I saw him and I couldn't bear to see him; it was something awful. He just began to slobber at the mouth when you spoke to him...And when he looked at you there wasn't anything in his eyes … it was like they were missing from his face, and his face, it had just come apart. Perez suffered a series of strokes that left him disabled and caused his death in 1946. ==Style and legacy==