Manuel Ruiz may refer to:Manuel Antonio Ruíz de la Rosa, Dominican Republic Roman Catholic bishop Manuel Ruiz Guerrero (1864–1917), Spanish painter and illustrator Manuel Ruiz de Lopera (1944–2024), Spanish businessman, owner of football club Real Betis Manuel Ruiz Pérez, Spanish football goalkeeper and manager Manuel Ruiz Sosa (1937–2009), Spanish football midfielder and manager Manuel Ruiz Urriés de Castilla (1734–1812), Spanish colonial official in the Viceroyalty of Peru Manuel Ruiz Zorrilla (1833–1895), Spanish politician, two-time prime minister in the 1870sManuel Ruiz Maya (1888–1936), Spanish physician and politician, executed by Francoist Spain Manuel Ruiz López, Roman Catholic saint, one of the 11 Martyrs of Damascus Manuel Ruiz, 19th-century Mexican politician, served two terms at the Secretariat of the Interior Manuel Ruiz, 19th-century Mexican politician, served two terms as governor of Tamaulipas