The gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the
serine/threonine-specific protein kinase family. This kinase can activate
ERK1,
ERK2 and
p38 MAP kinases. This kinase was shown to activate
IkappaB kinases, and thus induce the nuclear production of
NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1). This gene may also start transcription at a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. However, it functions in other organs as a oncogene, promoting cancer. == Interactions ==