Her first record production was titled
Ninel Conde (2003), which contains the song "Callados", played a duet with singer
José Manuel Figueroa. This material was nominated for a
Latin Grammy in 2004 for "Mejor álbum grupero." In 2004, Conde participated in the third edition of the reality show
Big Brother VIP and was voted-off after 43 days of confinement. In October 2004, she began acting on
Rebelde, produced by
Pedro Damián. Her most remarkable role so far has been this one. Her role as Alma Rey in
Rebelde (2004–2006) expanded her career to
Chile,
Romania,
Colombia,
Brazil,
Peru,
Spain and
Croatia. This show was nominated for the awards TVyNovelas 2006 as "Best Lead Actress." She was aLao involved in the films
7 mujeres, un homosexual y Carlos and
Mujeres infieles 2. In 2005 she released her second album
La Rebelde from which emerge the songs "Todo conmigo", "Ingrato", "Que no te asombre", and "Tú". Conde began appearing on the American
dramedy series
Ugly Betty where she portrays an actress on a "faux" telenovela that is seen by
the main character's family. She also participated in contest reality show titled
El Show de los Sueños, alongside
Pee Wee,
Kalimba Marichal,
Gloria Trevi,
DJ Flex/Nigga,
Mariana Seoane, and Priscila. In 2008, Conde played the character Rosario Montes in
Fuego en la sangre alongside
Adela Noriega and
Eduardo Yañez, where she was nominated by the participating TVyNovelas Award as "Best actress co-star." In August 2009, she was confirmed to appear in the
Mexican telenovela Mar de amor as Coral (main-villain of the story), the telenovela was produced by Natalie Lartilleux. This show was nominated for "Best Actress antagonistic." In 2012, Conde participated in the soap opera
Porque el amor manda as Discua Paz De La Soledad. In September 2013, Conde becomes a judge on the fourth season of
Univision's dancing competition
Mira quién baila. On June 16, 2025,
Colombian singer
Karol G released the trailer for her
Tropicoqueta album, inspired by
Mexican Telenovelas, where Conde reprised her role as Alma Rey from
Rebelde, along with fellow Mexican actresses
Anahí and
Itatí Cantoral. She was cast for the third season of reality show
La casa de los famosos México, set to premiere on 27 July 2025, by
Las Estrellas and
Canal 5. ==Personal life==