Marburgvirus

The genus Marburgvirus is the taxonomic home of Marburg marburgvirus, whose members are the two known marburgviruses, Marburg virus (MARV) and Ravn virus (RAVV). Both viruses cause Marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever. Both are select agents, World Health Organization Risk Group 4 Pathogens, National Institutes of Health/National Institute of Allergy and Infectious Diseases Category A Priority Pathogens, Centers for Disease Control and Prevention Category A Bioterrorism Agents, and are listed as Biological Agents for Export Control by the Australia Group.

Use of term

The genus Marburgvirus is a virological taxon included in the family Filoviridae, order Mononegavirales. The genus currently includes a single virus species, Marburg marburgvirus. ==Previous designations==

Previous designations

Until 1998, the family Filoviridae contained only one genus, Filovirus. Once it became clear that marburgviruses and ebolaviruses are fundamentally different, this genus was abolished and a genus "Marburg-like viruses" was established for marburgviruses. In 2002, the genus name was changed to Marburgvirus, and in 2010 and 2011 the genus was emended. ==Genus inclusion criteria==

Genus inclusion criteria

A virus that fulfills the criteria for being a member of the family Filoviridae is a member of the genus Marburgvirus if • its genome has one gene overlap • its fourth gene (GP) encodes only one protein (GP1,2) and cotranscriptional editing is not necessary for its expression • peak infectivity of its virions is association with particles ≈665 nm in length • its genome differs from that of Marburg virus by <50% at the nucleotide level • its virions show almost no antigenic cross reactivity with ebolavirions ==Genus organization==

Marburg marburgvirus

The species was introduced in 1998 as Marburg virus. In 2010, it was proposed to change the name to Marburg marburgvirus,) is a virological taxon (i.e. a man-made concept) included in the genus Marburgvirus, family Filoviridae, order Mononegavirales. The species has two virus members, Marburg virus (MARV) and Ravn virus (RAVV). The members of the species (i.e. the actual physical entities) are called Marburg marburgviruses. The name Marburg marburgvirus is derived from the city of Marburg in Hesse, West Germany (where Marburg virus was first discovered), and the taxonomic suffix marburgvirus (which denotes a marburgvirus species). ==Species inclusion criteria==

Species inclusion criteria

A virus that fulfills the criteria for being a member of the genus Marburgvirus is a member of the species Marburg marburgvirus if it has the properties of marburgviruses (because there is currently only marburgvirus species) and if its genome differs from that of Marburg virus (variant Musoke) by <30% at the nucleotide level. ==References==

Source: Wikipedia ↗

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