In 1987, he co-founded
Omega Pharma with Yvan Vindevogel. This Belgian pharmaceuticals company grew rapidly and in 2006 employed three thousand people whilst operating in thirty countries. He remained
Chief Executive Officer of Omega Pharma until 30 September 2006, returning to the post in March 2008. Whilst his business profile represents considerable achievement there have been highly publicised failures that include the launch of Omega Pharma's E-Waves phone Chip in 2008. It was withdrawn shortly after release as it did not work. In August 2021 Coucke, together with investment fund Waterland, was convicted to pay €266 million to pharmaceuticals company Perrigo in a dispute over the takeover of Omega Pharma. After selling Omega Pharma Coucke has become a major investor in mostly Belgian businesses with his investment company Alychlo across several sectors like real estate, construction, pharma, technology, food industry and entertainment. In Durbuy, he owns Adventure Valley, a golf club, a five-star hotel “Le Sanglier des Ardennes”, and "Les Jardins de Durbuy", which is a holiday park with 237 chalets. Most eye-catching was becoming the major shareholder and chairman of Belgian football club
RSC Anderlecht in January 2018 while he already did this before with
KV Oostende in 2013. In 2007, he was featured as a member of the jury in the television show
De bedenkers. ==Personal==