San Lorenzo Senesi made his debut for
San Lorenzo on 25 September 2016 as a starter in the
Argentine Primera División match against
Club Atlético Patronato. On 16 September 2017, he scored his first and only goal for the club in a 1–0 victory against
Arsenal de Sarandí.
Feyenoord On 2 September 2019, Senesi signed a four-year contract with Dutch football club Feyenoord. He made his debut for the club on 22 September 2019, in a 3–3 draw with
Emmen. On 10 November 2019, he scored his first goal for the club, the winning goal in a 3–2 victory against
RKC Waalwijk, heading in a free kick in the 85th minute.
Bournemouth On 8 August 2022, Senesi transferred to Premier League club
Bournemouth on a four-year contract for an undisclosed fee. He made his debut for the club on 13 August 2022, in a 4–0 defeat to
Manchester City. He scored his first goal for the club on 11 February 2023, in a 1–1 draw with
Newcastle United. ==International career==