After receiving her PhD, Lantis worked in several public agencies, including almost ten years with the
United States Public Health Service. In these positions she researched socialization, health, and economy in rural communities. Lantis was appointed professor of anthropology at the
University of Kentucky in 1965 By 1967 Lantis received
tenure at the university and was appointed to the graduate school faculty where she taught until her retirement in 1974. By the 1970s the University of Kentucky Press had published a collection of papers edited by Lantis in what they claimed as a relatively new field in anthropology-
ethnohistory Ethnohistory in South Western Alaska and the Southern Yukon: Method and Content was published in 1970 to which Lantis contributed a chapter on the Aleut. Towards the end of her career she continued to write about the people of Nunivak Island and the greater Alaskan territory as well as Southern Yukon. And applied topics The U.S
Bureau of Indian Affairs also published a series of lectures given by Lantis at a workshop in Anchorage Alaska in 1968. She also contributed a chapter on Arctic Aleut people to the
Handbook of North American Indians in 1984. While teaching graduate students at the University of Kentucky Lantis was also working with several committees and societies. She served as the president of the American Ethnological Society 1964-65 she was on the Polar Research Committee of the
National Academy of Sciences 1969-72 and was elected president of the
Society for Applied Anthropology 1973–74. She contributed a paper to the second volume published by the National Academy of Sciences on the earthquake entitled
Human Ecology of the Great Alaska Earthquake Lantis went on to publish another book on the disaster, titled
When the Earthquake hits Home: Anchorage in the "Great Alaska Earthquake" which explored how households in Anchorage coped with the disaster in the immediate emergency period and household practices that existed two years later. ==Later life==