Lock is the author or co-editor of 17 books and over 200 scholarly articles. Her first book,
East Asian Medicine in Urban Japan: Varieties of Medical Experience (1980), set the stage for over two decades of critically reflective comparative ethnographic research in Japan and North America in connection with disease and illness, life cycle transitions, and the body. This body of work makes clear that all medical knowledge, including that of
biomedicine, is embedded in specific historical, social, cultural, political, and economic contexts, with consequences for onto-epistemologies of medical knowledge and practice. Her first
monograph Encounters with Aging: Mythologies of Menopause in Japan and North America (Berkeley: University of California Press, 1993) is concerned with the medicalization of female
mid-life in Japan and North America. Lock created the concept of "local biologies" to account for the empirical findings generated by this research. This widely used concept de-centers the modernist assumption of a universal material body, and postulates ceaseless interactions among bodies, environments (evolutionary, historical, local), and social/political variables. Lock and Vinh-Kim Nguyen in their book
An Anthropology of Biomedicine (Oxford: Wiley-Blackwell, 2010) use the term "biosocial differentiation" to refer to the interactions of biological and social processes across time and space that sediment into local biologies.
Twice Dead: Organ Transplants and the Reinvention of Death (Berkeley: University of California Press, 2002) documents changes in the criteria for the determination of death made in the 1960s in order that organs could legally be procured for
transplant. In Japan, the possibility of organ procurement from brain dead bodies—entities whose life was not recognized as ended—caused major public unrest, with major consequences for the transplantation enterprise. Lock's most recent
ethnography,
The Alzheimer Conundrum: Entanglements of Dementia and Aging (Princeton: Princeton University Press, 2013) highlights the "molecularized prevention" of
Alzheimer's disease in which tracking of somatic
biomarkers is central, however, the presence of such biomarkers does not determine a future occurrence of Alzheimer's. She is working currently on the burgeoning discipline of
epigenetics, which confronts the age-old debate of
nature versus nurture. == Awards and honors ==