Wrightson received many commissions throughout her long career. Wrightson created a sculpture of a woman titled ‘Mechanic, Women’s Army Auxiliary Corps’ in 1917 that was later exhibited at the Royal Academy; the work had been suggested as a war memorial. In 1925 she created a 'Viking Warrior' for Walter Runciman. Wrightston's memorial of Admiral Earl Jellicoe stands in
St Paul's Cathedral, London. Other public works include the figure of Saint George on the Cramlington war memorial in Northumberland, created in 1922, and a figure memorialising Charles Lamb, situated in the Inner Temple gardens, London. The work was restored in 2012 after originally being commissioned in 1925, and erected in 1928. Wrightson became an Associate member of the
Royal Society of British Sculptors in 1929 and a Fellow in 1943. She was also a member of the
Royal Academy. == Works ==