Amante-Matba started her political career as the governor of
Agusan del Norte serving three consecutive terms from 1995 to 2004. At the time, she was the youngest provincial governor assuming office at only 25 years old. From 1995 to 1998, she was the chairperson of the Regional Development Council of
Caraga. She served for one term before running as mayor of
Butuan in 2007 which she lost to incumbent
Democrito Plaza. In 2010, she ran for congress again while her brother ran for governor. They both won their respective races. In 2013 and 2016, Amante-Matba and her brother swapped their positions wherein the latter served as congressman while Amante-Matba served governor. They won and Amante-Matba served as governor until 2019. She ran and won again the congressional seat in 2019 and served for one term before returning as governor in 2022. ==2016 presidential elections==