De Koninck devoted a good portion of his philosophical work to the philosophy of nature. De Koninck's graduate career at Louvain led him to write a dissertation under Fernand Renoirte, himself a philosopher of science, on the philosophy of
Sir Arthur Eddington. His dissertation attempted to parlay between classical Thomistic philosophy and Eddington's philosophy of science, shaped by recent developments in relativity theory and quantum theory. While De Koninck's initial view of the relationship between philosophy and the experimental sciences followed a separatist line akin to that of
Jacques Maritain, a later development in his thinking portrayed the modern sciences as "dialectical extensions" of metaphysics and, more proximately, the philosophy of nature. Over the course of his career, De Koninck published articles addressing overlapping issues in classical Aristotelian and Thomistic philosophy and quantum indeterminism, the biological sciences, the foundation of mathematical physics, and the philosophy of mathematics. The most accessible introduction to his thought in the philosophy of nature and science is his Whidden Lectures of 1959, published as a collection titled
The Hollow Universe. In the three lectures, De Koninck addresses the philosophical foundations, content, and implications of three modern scientific inquiries: modern mathematics ("The World of Symbolic Construction, or Two is One Twice Over"), physics ("Mental Construction and the Test of Experience"), and biology ("The Lifeless World of Biology"). The epilogue to the book, "Reckoning with the Computers," extends the theme of the hollow universe from the realm of mathematics, physics, and biology to the account of man himself. Scholar Leslie Armour maintains that "our place as knowing beings suggests to De Koninck that nature and knowing beings are so designed as to go together, and so designed as to be unintelligible without one another." =="Common good" controversy==