At the death of her spouse in 1859, she intended to continue her political activity by being the advisor to her stepson Francis, who was the new monarch. Francis was willing, and her authoritarian policy has been considered to contribute to the public discontent which led to the abolishment of the Kingdom of the Two Sicilies. Francis' spouse
Duchess Maria Sophia in Bavaria, however, disputed her influence and Francis had a difficult position in the conflict between his wife and stepmother, without being able to satisfy either. Maria Sophia informed Francis about a plot created by Maria Theresa with the attempt to put the biological son of Maria Theresa on the throne, but Francis chose to believe Maria Theresa when she swore her innocence. It was not until the revolts against the monarchy had already begun that Francis decided to listen to the advice of his wife rather than his stepmother. It was first believed that Maria Theresa would take up exile in Vienna, however, she was among the first to leave Naples during the revolt: first to
Gaeta with her children and advisors, and then to Rome. She resided in the same palace that Francis and Maria Sophia would use when they arrived. She died from
cholera, nursed by her stepson Francis, who mourned her greatly. ==Issue==