2005–2006: Turning professional In 2005, she appeared in her first
WTA Tour qualifying in
Bogotá and also played on the
ITF Women's Circuit. In the
2005 Bolivarian Games, she won the silver medal in singles and in doubles. Duque fell 2006 in the qualifying in Bogotá, won three singles and three doubles titles on the ITF Circuit.
2007 In her third full season on the tour, she arrived in the first round defeating compatriot
Viky Núñez Fuentes and was beaten in the second by
Flavia Pennetta. The same year, she won three singles titles on the ITF Circuit. At the
Junior French Open, in her first appearance in a
Grand Slam tournament, she finished runner-up, making history for Colombia as the first tennis player to reach such instance. In
Pan American Games, she arrived at the end confronting Venezuelan
Milagros Sequera; the top-seed and favorite took home the gold medal for Venezuela and Mariana the silver medal, being one of the best achievements in her career. She also got the silver medal in doubles with compatriot
Karen Castiblanco.
2008 At the
US Open, Duque Mariño advanced to the second round by coming back to beat
Tamarine Tanasugarn, ranked 19th in the world, after having lost the first set 0–6. In the second round, she lost in straight sets to
Agnieszka Radwańska, ranked No. 9 in the world. Thanks to this presentation, she got into the top 100 players in the world for the first time by moving up two sports: 101 to 99. She was also present at the WTA Tour event of Bogotá, where in the first round she confronted
Jelena Kostanić Tošić, winning in straight sets. In the second round, she faced
Yvonne Meusburger being the fifth seed in the tournament and against which Mariana Duque wins, in straight sets. In the quarterfinals, she confronted
María Emilia Salerni to which Mariana fell in three sets. In the first round of the
Portugal Open, she won in straight sets against
Monica Niculescu. In the second round, she fell to
Karin Knapp who was seeded No. 3 in the tournament. Duque Mariño won two singles titles and two doubles titles on the ITF Circuit.
2010–2014 Playing in her home country, Duque Mariño claimed her very first WTA Tour title at the Copa Colsanitas defeating
Gréta Arn,
Kristina Antoniychuk, seventh seed
Klára Zakopalová, eighth seed
Arantxa Parra Santonja, and fifth seed
Angelique Kerber. Duque Mariño became the second Colombian woman to claim this title since
Fabiola Zuluaga did it in 2004. At the
2012 Summer Olympics, she competed in the women's singles, but was knocked out in the first round by
Maria Kirilenko.
2015: Gold at Pan Am Games, and career-high WTA ranking On 11 through 16 July, Duque Mariño competed at the
Pan American Games where she won a gold medal. The world No. 89 ousted the tournament's top-seed
Lauren Davis in the semifinal stage of the tournament, while her opponent
Victoria Rodríguez reached the final by taking out the second seeded
Monica Puig. Yet when they crossed paths in the final, it was Duque Mariño who shone brightest. This marked the first time in the history of women's tennis a Colombian woman had won a gold medal. Duque Mariño reached for the first time in her career the third round of a Grand Slam championship, where she beat American wildcard
Sofia Kenin in the first round and
Océane Dodin in the second. Duque is the second Colombian player to reach third round at the US Open, after
Fabiola Zuluaga. In the third round, she faced former world No. 11,
Roberta Vinci, and fell in three sets. Duque Mariño kicked off the Asian swing at the
Korea Open where she advanced to the second round defeating
Kiki Bertens, before losing to fifth seed
Mona Barthel, in straight sets. At the
Wuhan Open, she qualified by defeating
Casey Dellacqua and
Christina McHale but failed to keep her momentum going when she lost to rising star
Anna Karolína Schmiedlová, in straight sets. At the
China Open, Duque Mariño breezed through qualifying by defeating wildcard
Xu Yifan and
Magda Linette both in straight sets. She set up a first-round match against former Wimbledon semifinalist
Tsvetana Pironkova and defeated her in straight sets. She lost to eventual runner-up and No. 12 seed,
Timea Bacsinszky. With her result at the China Open, Duque Mariño moved up the rankings to No. 66, making it her highest ranking.
2016: Second WTA Tour final since 2010, and quarterfinals at Mallorca Open Duque Mariño reached final at the
Nürnberger Versicherungscup by defeating
Carina Witthöft,
Laura Siegemund,
Varvara Lepchenko, and
Annika Beck. She lost her final match against Kiki Bertens, in straight sets. In June at the
Mallorca Open, she defeated No. 134
Alison Van Uytvanck, and then 2013-Wimbledon finalist and ex-No. 12,
Sabine Lisicki, in three sets. However, in the third round she lost to
Anastasija Sevastova. At the
2016 Summer Olympics in August, she lost in the first round of the singles draw to Angelique Kerber. ==Performance timelines==