Rosenzweg was hired by the
University of California, Berkeley in 1949 as an assistant professorship in
physiological psychology, and remained on its faculty until he retired in 1991. Dissatisfied with existing textbooks in
biological psychology, he and colleague Arnold Leiman wrote a textbook in the 1980s that is still in print. Rosenzweig initiated experimental research upon
enriched environment and the brain.
Donald O. Hebb, in 1947, had found that rats raised as pets performed better on problem solving tests than rats raised in cages. But his research did not investigate the brain directly nor use standardized impoverished and enriched environments. Mark Rosenzweig with his colleagues
David Krech, Edward Bennett and
Marian Diamond started this research in the late 1950s by comparing single rats in normal cages, and those placed in ones with toys, ladders, tunnels, running wheels in groups. They found that growing up in enriched environments affected activity of the enzyme
cholinesterase in the brain. This work led in 1962 to the discovery that environmental enrichment increased
cerebral cortex volume. He published details of his research in the book
Enriched and Impoverished Environments: Effects on Brain and Behavior in 1987. These findings contradicted the prevailing scientific theory that the brain's structure was fixed before adulthood and that later learning and experience did not affect its structure. Later research confirmed that the changes occurred in adulthood and were not tied to differences in diet. and with
Lyman Porter from 1975 to 1994. Rosenzweig retired from UC Berkeley in 1991. The
American Psychological Association recognized him with its Distinguished Scientific Contribution Award in 1982. ==Personal life and death==