Canton worked as executive vice president at
Warner Bros. from 1980 onwards. Successes he was involved in at the time include 1983's ''
National Lampoon's Vacation, Purple Rain, and the Batman and Lethal Weapon film series, but also notorious box office failures like The Bonfire of the Vanities'' (1990), a picture he described as "the best movie I ever saw" at its first screening. In 1991, Canton quit
Warner Bros. where he was executive vice president of the Worldwide Motion Picture Production unit. Warner Bros. let him out of his contract fifteen months early with studio head
Bob Daly saying "from our standpoint this was a job that was going to be eliminated." He then became chairman of
Sony's
Columbia Pictures (later
Columbia-TriStar Pictures), where he was involved with some failures like
Geronimo: An American Legend, but also with blockbusters such as
Men in Black,
Air Force One, and ''
My Best Friend's Wedding.) and The Cable Guy'', before his final string of movies could become blockbusters. Described at the time as both "known for enthusiasm, rapid-fire talk, a sleek Italian wardrobe and a youthful style" Canton was in those years "one of the most powerful executives in Hollywood". Backed by the German company Senator Entertainment from August 2000 onwards, he struck a first-look deal with Warner Bros. By the end of 2001, the shares of Senator had dropped substantially and Canton had to close down his production company. In 2002, he was the chief executive of Artists Production Group, the movie branch of
Artist Management Group. With this company, he produced blockbusters such as
300,
Immortals, and
The Spiderwick Chronicles. In 2014, Canton co-created the show
Power alongside
Curtis '50 Cent' Jackson and Courtney Kemp, which earned numerous NAACP Image Awards, including multiple Outstanding Drama Series awards, National Film & Television Awards, People's Choice Awards and BET Awards. This series was the number-one show on premium cable for its six-year run from 2014-2020. In 2026, Canton joined forces with
Peter Guber at
Mandalay Entertainment as a managing partner for a new wave of feature films while continuing to develop television independently. In his roles as executive, chairman, and producer, Canton has been involved in over 300 major Hollywood productions. ==Other activities and roles==