In the years 2016 and 2017, Mark Padun raced for . In 2017, he won a stage of the
Giro Ciclistico d'Italia and after
Matija Kvasina, winner of the 2017
Flèche du Sud, tested positive for EPO, Padun's second place was upgraded to first overall.
Bahrain–Merida (2018–2021) In August 2017, Padun joined as a stagiaire, and received a regular contract for the next season. In
2018 and
2019, he raced in the
Vuelta a España. In 2019, he won the
Ukrainian National Time Trial Championships. In October 2020, he raced in the
Giro d'Italia and finished in second place on stage 12. In 2021, Padun won Stages 7 and 8 of the
Critérium du Dauphiné, after spending each day in the breakaway, while also collecting enough points to win the mountains classification. By dropping his companions in the breakaway and holding off the group of favorites on two consecutive days, these wins sparked sceptic commentary from riders and staff of other teams. The French newspaper
Le Parisien published quotes calling his performance "an absolute disgrace" and that it "reminds us of the dirty 2000s". Despite his strong performance, he was not nominated for the
Tour de France by his team, nor was he taken to the
Men's individual road race at the delayed
2020 Summer Olympics by his federation, to the surprise of observers. In an interview with ''
L'Équipe'', he defended himself against
doping suspicions, citing weight problems as reason for his inconsistent performances.
EF Education–EasyPost (2022–2023) For the 2022 season, he signed a contract at . Team manager
Jonathan Vaughters emphasised his trust in Padun, and justified it with "physiological tests" and "instinct". In February, Padun won stage 4 of
O Gran Camiño, his first top ten in a time trial against an international field.
Team Corratec–Vini Fantini (2024) He signed a one year contract with
UCI ProTeam in January 2024. Padun announced his retirement in January 2025. ==Major results==