Pellegrino's first appearance into television was on season 2, episode 2 of the series
L.A. Law. His debut film role was that of a narcotics dealer in 1987's
Fatal Beauty. Some of his earlier television appearances are also in
Northern Exposure,
Tales from the Crypt,
ER,
Without a Trace,
NYPD Blue,
CSI: Crime Scene Investigation,
Hunter, and
The Commish. In 1989, he portrayed
Hulk Hogan's younger brother in
No Holds Barred. In 1991, he co-starred in
Prayer of the Rollerboys as
Christopher Collet's aide-de-camp. In 1998, he played the Blonde Treehorn Thug who stuffs The Dude's head down the toilet and drops his bowling ball, breaking the floor tile, in the cult film
The Big Lebowski. In 1999, he appeared in season 7, episode 3 of
The X-Files as a disgruntled fast food joint employee. He was featured in
National Treasure as the background FBI agent known as Agent Johnson. In 2001, he played a hitman in
David Lynch's critically acclaimed
Mulholland Drive. He portrayed terrorist bomber Bobby James on
The Beast. In 2005, he appeared in the
Academy Award winning film
Capote, playing murderer
Dick Hickock. In 2006, he played Sadik Marku, an Albanian mob boss, in two episodes of
Without a Trace. The first episode was in season 4, episode 22 where he guest starred alongside
Mark Sheppard who played
Crowley in
Supernatural. The second episode was in season 5, episode 5 where he guest starred alongside
Rachel Miner who played
Meg Masters also which is a role in
Supernatural. In March 2009, he was cast on the ABC series
Lost for an appearance in the final 2 episodes of Season 5, to play the role of the mysterious
Jacob. Although the press release for the episode refers to his character simply as man No. 1, the episode revealed that he portrayed Jacob, a mysterious character pivotal to the show's plot. On June 26, 2009, it was also announced that he was cast in a recurring role as
Lucifer in season
5 of the CW series
Supernatural. He played a recurring role as Lucifer in season
7, and a main role as his character in seasons
12 and
13. He played a main role in season
14 as
Nick, Lucifer's vessel, and was a special guest in season
15. In 2011 he portrayed James Bishop, the leader of a vampire clan based in Boston, in the
SyFy horror series
Being Human in the first season, and reprised his role in seasons 2-4 as a recurring guest. In 2011, he and
Curtis Armstrong, who played
Metatron on Supernatural, guest starred alongside each other as well as their characters being enemy lawyers in season 7 of
The Closer. In 2012, he played a man that took a hit out on his wife, who also took one out on him, Daniel Drake in season 2, episode 8 of
Person of Interest. In 2015, he joined the
ABC thriller series
Quantico playing the recurring role of Clayton Haas. In 2018, he voiced and motion captured his first video game role as antagonist Jacob Seed in one
Ubisoft's
Far Cry 5. In 2021 and 2024, he played Virgil Poe in the
American Rust TV series, a show based on
the novel of the same name written by
Philipp Meyer. In July 2024, he appeared in
Beverly Hills Cop: Axel F as one of Captain Cade Grant's, played by
Kevin Bacon, main man antagonist named Beck. ==Personal life==