Indianapolis Colts 2017 season The
Indianapolis Colts selected Mack in the fourth round (143rd overall) of the 2017 NFL draft. Mack became the first
running back to be drafted from the University of South Florida and was the 15th running back drafted in 2017. He was the 28th USF player to be selected in the history of the
NFL draft. On May 17, 2017, the Colts signed Mack to a four-year, $2.81 million contract that includes a
signing bonus of $419,648. Throughout
training camp, Mack competed to be the primary backup running back against
Robert Turbin and
Josh Ferguson. Head coach
Chuck Pagano named Mack the third running back on the Colts’ depth chart to begin the regular season, behind
Frank Gore and Turbin. in December 2017 Mack made his NFL debut in the season-opener at the
Los Angeles Rams and had ten carries for 24 yards. He scored his first NFL touchdown on a three-yard carry during the fourth quarter of their 46–9 loss. In addition, he made his first career reception on a 21-yard pass from quarterback
Scott Tolzien and fumbled once. Mack was inactive for two games (Weeks 3–4) due to a shoulder injury. In Week 5, Mack had nine carries for a season-high 91 rushing yards and a touchdown during a 26–23 overtime victory against the
San Francisco 49ers. Three weeks later, Mack had a season-high 11 carries for 27 yards and caught three passes for 36 yards and made his first touchdown reception on a 24-yard pass from quarterback
Jacoby Brissett during the third quarter as the Colts narrowly lost 24–23 at the
Cincinnati Bengals in Week 8. Mack finished his rookie year with 93 carries for 358 rushing yards and three rushing touchdowns to go along with 21 receptions for 225 receiving yards and one receiving touchdown in 14 games.
2018 season Mack entered training camp slated as the starting running back after
Frank Gore departed in free agency. Mack was named the starting running back to begin the regular season. Mack was inactive for the season-opening 34–23 loss against the Bengals after suffering a hamstring injury in the first preseason game. Mack was sidelined for three consecutive games (Weeks 3–5) after aggravating his hamstring injury. In Week 7, Mack had 19 carries for 126 rushing yards and two touchdowns during a 37–5 victory against the
Buffalo Bills. On October 28, 2018, Mack ran the ball 25 times for 132 yards and two touchdowns in the Colts 42–28 win at the
Oakland Raiders in a Week 8. He became the first Colts running back since
Joseph Addai in 2007 to post back-to-back 100-yard rushing games. During Week 15, Mack had a season-high 27 carries for 139 rushing yards and two touchdowns during a 23–0 win over the
Dallas Cowboys. He was just the second player all season to rush for over 100 yards against the Cowboys, and the first since 2015 to run for 100 yards and two scores. He also became just the third player in Colts franchise history to have multiple games with at least 125 yards rushing and two touchdowns in the same season, joining
Eric Dickerson (1987) and
Edgerrin James (1999 and 2005). Mack finished his second season with 908 rushing yards and nine rushing touchdowns. He added 17 receptions for 103 yards and a touchdown. The Colts made the playoffs as the No. 6 seed. In the
Wild Card Round against the
Houston Texans, Mack set a franchise postseason record with 148 yards and a touchdown on 24 carries in a 21–7 victory. In the
Divisional Round against the
Kansas City Chiefs, he had nine carries for 46 yards in the 31–13 loss.
2019 season During the season-opener against the
Los Angeles Chargers, Mack rushed 25 times for 174 yards which included a career-high 63-yard touchdown run in the 24–30 overtime loss. In Week 3 against the
Atlanta Falcons, Mack rushed 16 times for 74 yards and a touchdown as the Colts won 27–24. In week 5 against the
Kansas City Chiefs, Mack rushed 29 times for 132 yards and caught three passes for 16 yards in the 19–13 win. During Week 11 against the
Jacksonville Jaguars, Mack finished with 109 rushing yards and a touchdown before fracturing his hand in the 33–13 win. In the 2019 season, Mack finished with 1,091 rushing yards and eight rushing touchdowns.
2020 season During Week 1 against the Jaguars, Mack left the game with an injury. An MRI revealed that Mack had suffered a torn Achilles and was ruled out for the rest of the season. He was placed on
injured reserve on September 16.
2021 season Mack re-signed with the Colts on March 23, 2021. In six games, he finished with 28 carries for 101 rushing yards.
Houston Texans On April 11, 2022, Mack signed with the Texans. He was released on August 30, 2022, and signed to the practice squad the next day. He was released on September 5.
San Francisco 49ers On September 14, 2022, the 49ers signed Mack to their
practice squad. He was promoted to the active roster on September 21. He was released on October 11. He signed back to the practice squad the following day.
Denver Broncos On October 24, 2022, the
Denver Broncos signed Mack off the 49ers' practice squad. He went on to play six games, recording 84 rushing yards and a rushing touchdown, along with eight catches for 99 receiving yards and a receiving touchdown. After suffering a hamstring injury in Week 17 against the
Kansas City Chiefs, Mack was placed on season–ending injured reserve.
Arizona Cardinals On August 4, 2023, Mack signed with the
Arizona Cardinals. On August 9, 2023, head coach
Jonathan Gannon announced that Mack would miss the 2023 season due to another torn Achilles. ==Career statistics==