When Louisiana's Reconstruction government began the work necessary to be readmitted to the Union, Twitchell was elected as a delegate to the state's 1868 constitutional convention. In 1869, he was elected to the first of two four-year terms in the state senate, having won critical
African American support because of his championing of their causes and the individual friendships he had established with many freedmen in his district. He was the principal force behind the creation of
Red River Parish and the establishment of Coushatta as the
parish seat. When the parish
police jury was elected in 1871, Twitchell was chosen as its president, making him the head of the parish government and the parish school superintendent. He appointed relatives and political supporters to key positions and was influential in improving the education of his black supporters by organizing
segregated public schools in Bienville, Red River, and
De Soto parishes. Among the tactics Twitchell used to protect the schools for black residents was threatening to withhold signatures on the warrants authorizing pay for teachers at all the parish schools. Twitchell's life was constantly in danger, and he was targeted several times by assassins. In 1874, Twitchell's only brother, Homer and two brothers-in-law, Clark Holland and Monroe Willis, were murdered in the
Coushatta massacre. The massacre was an attempt by Democrats in Red River Parish to seize control of the local government by killing or disenfranchising Republicans, including the parish's African-American residents. Twitchell obtained federal authority to investigate, which led to the arrest of several prominent individuals, exacerbating tension between Twitchell and the pro-Confederate Democrats who were attempting to reclaim political power in Louisiana.
Assassination attempt On May 2, 1876, an assassin armed with a rifle attempted to kill Twitchell while he was traveling by boat to Coushatta, the Red River Parish seat. He was wounded six times, which required the amputation of both arms above the elbow. His brother-in-law, George A. King, was killed in the attack. Twitchell would also have been killed, but when he pretended to be dead, the shooter stopped firing. Had the shooter succeeded, the partisan balance in the State Senate would have placed
Redeemer Democrats in the majority. A Democratic senate would have ended Republican control of Louisiana by recognizing a Democratic
Louisiana House of Representatives and governor, and electing a Democratic U.S. senator. Twitchell's property was abandoned or seized in court proceedings in the years after the attempted assassination. His neighbors had reportedly been jealous of his political and economic success during the downturn caused by the
Panic of 1873 and were not upset to see him ruined. Two of his sisters died in Louisiana, with stress and heartbreak from the deaths of their relatives a contributing factor. ==Later years==