Characters and setting ''Marvel's Spider-Man 2
is set 10 months after the events of Spider-Man: Miles Morales (2020). Yuri Watanabe (Tara Platt), a disgraced former police captain and ally of Peter who has assumed the vigilante identity of "Wraith" following the events of The City That Never Sleeps; J. Jonah Jameson (Darin De Paul), the Daily Bugle''s chief editor and Mary Jane's boss;
Danika Hart (
Ashly Burch), host of the "Danikast" podcast; Peter's deceased aunt,
May (
Nancy Linari), who is featured in a
flashback; and Miles' late father, Officer
Jefferson Davis (Russell Richardson), who appears in a
dream sequence. Throughout the city, the two Spider-Men are faced with several supervillains such as
Venom (
Tony Todd), an extraterrestrial
symbiote capable of bonding to human bodies and granting regenerative powers while negatively influencing their behavior;
Sergei Kravinoff / Kraven the Hunter (
Jim Pirri), the leader of a faction of
mercenaries called the "Hunters" who seek to hunt super-powered beings; and
Cletus Kasady (
Chad Doreck), also known as "The Flame", the head of a nihilistic cult who seeks to perform a demonic ritual to bring about an
eschatological event dubbed the "Crimson Hour". Returning villains from the first game include
Martin Li / Mister Negative (
Stephen Oyoung),
Mac Gargan / Scorpion (
Jason Spisak),
Lonnie Lincoln / Tombstone (Corey Jones), and
Felicia Hardy / Black Cat (
Erica Lindbeck). Additional antagonists who were referenced in prior entries make full appearances in
Spider-Man 2, including
Flint Marko / Sandman (Leandro Cano), a lowly burglar who, through an accident, gained the ability to turn into molecules of sand and manipulate them at will;
Curt Connors / Lizard (Mark Whitten), an Oscorp scientist who transformed into a giant reptilian creature;
Dmitri Smerdyakov / Chameleon (Jim Pirri), a criminal master of disguises and Kraven's half-brother; and
Quentin Beck / Mysterio (Noshir Dalal), a visual effects artist and reformed criminal who became the head developer of a
virtual reality entertainment attraction called "Mysterium". Furthermore,
Otto Octavius / Doctor Octopus (
William Salyers), who is incarcerated in
the Raft after the events of the first game, appears in a
mid-credits scene. The character
Cindy Moon makes a non-speaking
cameo appearance in the game's post-credits scene, along with her father
Albert Moon (
Tom Choi). The character
Delilah, a skilled assassin who serves as the bartender at the Bar with No Name in an
alternate universe, makes a cameo appearance during "The Message" side-quest. This version of the character was originally intended to appear in
Spider-Man: Across the Spider-Verse (2023) before her scene was cut from the final film.
Plot 10 months after the events of
Marvel's Spider-Man: Miles Morales, Peter starts his first day as a physics teacher at Brooklyn Visions Academy with Miles among his students, but they are interrupted by a rampaging
Sandman, requiring both the Spider-Men to subdue him. Fired for abandoning the class, Peter returns to his Aunt May's home in Queens–which he has moved into following her death–to meet with Mary Jane. They are surprised by Harry, who has miraculously recovered from his terminal illness. Harry hires Peter to work at his
environmental technology startup, the Emily-May Foundation (named after Aunt May and Harry's mother Emily), so they can pursue his dream of "healing the world". Concurrently,
Kraven and his Hunters arrive to New York. While overseeing a prison transfer with Peter at
The Raft, a vengeful Miles fails to stop the Hunters from capturing
Martin Li, who previously killed his father, Jefferson Davis. Investigating Kraven, Peter discovers he is hunting super-powered individuals in search of an "equal". Having already killed
Scorpion,
Vulture,
Shocker, and
Electro, Kraven attempts to capture
Black Cat. However, Miles helps her escape to
Paris by using the mystical
Wand of Watoomb. Peter, Mary Jane, and Harry visit
Coney Island to reconnect; while there, the Hunters attack the park to capture a reformed
Tombstone. While Peter rescues civilians, he is assisted by a super-powered Harry, who learns about Peter's double life. Harry reveals that, on his father Norman Osborn's insistence, he was cured by Curt Connors via a powerful organic exosuit that physically augments his body. With the exosuit's powers rapidly developing, Harry helps Peter rescue Tombstone while Mary Jane discovers that Kraven has kidnapped Connors. The trio attempt to save Connors, but Kraven forcibly turns him back into the
Lizard, steals the serum needed to transform him back and mortally wounds Peter. Before Peter can die, the exosuit transfers itself from Harry to Peter's body, saving him. After Peter viciously defeats the Hunters with his newly enhanced powers, Kraven develops an interest in hunting Peter personally. Peter reunites with Harry and Mary Jane and attempts to return the suit to Harry, but it refuses to leave him; the three figure they need Connors' help. While investigating Kraven, Peter discovers that Kraven is dying of
cancer and is looking for someone who can give him a "warrior's death" in combat. Peter manages to retrieve the serum from Kraven, who discovers the exosuit's weakness to loud noises. After Peter and Harry synthesize an antidote for Connors, Peter locates him with Miles' help and eventually defeats and cures him. Upon seeing Peter wearing the exosuit, Connors reveals that it is actually an alien lifeform called a
symbiote, which Oscorp obtained years prior from a meteorite, and warns Peter to destroy it. Under the symbiote's corrupting influence, Peter refuses and keeps it for himself despite learning that Harry's illness has returned, straining their friendship. As Peter goes on a symbiote-induced rampage against the Hunters (even nearly killing Mary Jane at one point), Kraven captures Miles and forces him to fight Li. Miles overcomes his anger towards Li and helps him escape, directing him to find Peter. Once Li informs him of Miles' location, Peter arrives to storm Kraven's fortress in an effort to rescue him and nearly kills Kraven before Miles intervenes, defeating the corrupted Peter and convincing him to remove the symbiote. Peter takes the symbiote to Oscorp to destroy it, but a desperate Harry intercepts him and reclaims it, transforming into a monstrous creature. After slaughtering Oscorp staff trying to remove the symbiote from him, the symbiote-induced Harry escapes into
Times Square, where he defeats several of Kraven's Hunters before overpowering and killing Kraven himself. The symbiote convinces Harry to "heal the world" by infecting everyone on Earth with symbiotes, starting with New York. Dubbing themselves "
Venom", Harry and the symbiote transform Mary Jane into
Scream, but Peter helps her break free after battling and reconciling with her. As Peter and Miles attempt to stop Venom, Peter is debilitated by a trace amount of the symbiote still within him. After Miles settles his differences with Li, the latter uses his powers to convert Peter's symbiote traces into the
Anti-Venom symbiote, which can destroy other symbiotes. Concurrently, Venom recovers the meteorite that originally brought him to Earth and empowers himself with it, accelerating his infestation on New York. Peter and Miles distract Venom while Mary Jane steals the meteorite and destroys it with the EMF's
particle accelerator, destroying Venom's symbiote horde. At Harry's insistence, Peter destroys the symbiote and frees Harry from its control, but renders Harry comatose. In the aftermath, Mary Jane quits the
Daily Bugle to run her own podcast and moves in with Peter, who opts to take a break from being Spider-Man to focus on rebuilding the EMF, trusting Miles to protect the city on his own. Meanwhile, Norman blames the Spider-Men for ruining Harry's recovery; he visits an imprisoned Otto Octavius at the Raft to demand their secret identities, but Octavius refuses, taking glee in Norman's suffering. Miles completes his college essay and meets Rio's new boyfriend, Albert Moon, who introduces them to his daughter
Cindy. ==Development==