Mary Hume-Rothery called for
universal suffrage in April 1867, in the
Manchester Examiner and Times. She put more emphasis on principle than
Lydia Becker, also in the Manchester area, and other more incremental campaigners. She was a leading figure in the
Ladies National Association for the Repeal of the Contagious Diseases Acts (LNA) set up in 1869. She was one of the prominent leaders in the LNA's campaign against the
Contagious Diseases Acts of 1864, with
Josephine Butler,
Harriet Martineau and Sarah Richardson. She was a prominent invited speaker for the LNA. Mary published in 1870
A Letter Addressed to the Right Hon. W. E. Gladstone. This open letter questioned the line drawn between conventional marriage and prostitution. In December William Hume-Rothery wrote, from 3 Richmond Terrace, Middleton, an extended letter in support of the Anti-Vaccination Society to the editor of the
Cosmopolitan, referring to coverage in
The Globe and an earlier letter of his from 1869. In 1871 Mary Hume-Rothery published
Women and Doctors; Or, Medical Despotism in England. Its message was to resist government control that discriminated against medicine that was not from trained doctors. Her mentor, Tulk, was an enthusiast for
phrenology and
mesmerism. She attributed her own conversion to anti-vaccination to seeing her own child vaccinated, around 1867. In 1874 Mary and William founded the
National Anti Compulsory Vaccination League (NACVL). William led the
anti-vaccination organisation and Mary was the secretary. For some years Cheltenham became the centre of the national movement opposing vaccination, and Mary edited its magazine. In
Keighley, Poor Law Guardians were imprisoned, following resistance tactics against vaccination advocated by William. A short notice in the
British Medical Journal in 1876 mentioned "the efficacy and value of vaccination" and the need for evidence to counterbalance "such irrational and dangerous agitators as Stevens and Hume Rothery." ==Last years==