In August 2023, Sheffield set up an
exploratory committee for a candidacy for
mayor of Detroit in the
2025 election, hiring
Nick Rathod as an advisor. Following the decision of
Mike Duggan, the incumbent mayor, to not seek another term, Sheffield announced her candidacy to succeed him in December 2024. During her mayoral campaign she campaigned on investing in underserved neighborhoods, saying in her primary election victory speech, "I do believe that our neighborhoods need more investment without a doubt. We are going to elevate issues and ensure that we're bringing more attention to our communities." Sheffield placed first in the primary election, and advanced to the general election in November. She defeated
Solomon Kinloch Jr., becoming the first woman to be elected mayor of Detroit. She was sworn into office on January 1, 2026. == Personal life ==