Having turned professional after the Olympics, Spencer was undefeated in her first six pro-fights and in her seventh contest won the
WBA female International and
WBC female Silver super-welterweight titles with a first-round stoppage success over the previously unbeaten Mexican boxer Cynthia Lozano in Montreal, Canada, on 9 September 2022. Next she took on Belgian boxer
Femke Hermans for the vacant
IBO female
super-welterweight World title losing the bout in Shawnigan, Quebec, Canada, on 16 December 2022 by unanimous decision. A rematch was held on 11 October 2023, in Montreal, Canada, with the IBO belt and the vacant
IBF female super-welterweight title up for grabs. Once again Hermans got the victory, this time by majority decision. Spencer snapped her losing streak with a win over Sonya Dreiling on 25 January 2024, taking victory via retirement when her American opponent failed to answer the bell at the start of round two.
WBA Super-Welterweight champion Spencer vs. Mannes On 5 September 2024 at
Montreal Casino, Quebec, Canada, Spencer defeated Naomi Mannes by unanimous decision to win the
interim WBA super-welterweight title.
Spencer vs. Suárez Spencer was elevated to a full champion after
Terri Harper vacated the title. She made her first defense against
Ogleidis Suárez back at Montreal Casino on 10 April 2025, winning by unanimous decision.
Unified Super-Welterweight Championship Spencer vs. Mayer Spencer defended her WBA title against
Mikaela Mayer at Montreal Casino on 30 October 2025. The vacant WBC and
WBO female super-welterweight championships were also on the line. Spencer lost by unanimous decision.
Unified Middleweight Championship Spencer vs. Robinson Spencer is scheduled to challenge
Desley Robinson for her unified IBF and WBO middleweight titles at
El Paso County Coliseum in El Paso, Texas, on May 30, 2026. ==Personal life==