MD 260 begins at a partial
trumpet interchange with MD 4 (Southern Maryland Boulevard) at Lyons Creek, which forms part of the Calvert–
Anne Arundel county border. There is no access from westbound MD 260 to southbound MD 4; that movement is made by following northbound MD 4 into Anne Arundel County and making a U-turn at the Lower Pindell Road intersection. MD 260 heads southeast as a two-lane undivided road on a straight path for almost . The highway crosses a pair of tributaries of Hall Creek, running north of the historic home
Maidstone and passing through the southwestern corner of Anne Arundel County. Immediately after re-entering Calvert County, MD 260 temporarily expands to four lanes for its intersection with MD 2 (Solomons Island Road). The highway continues through
Owings, where the highway intersects
MD 778 (Old Solomons Island Road). Southeast of Owings, MD 260 crosses Hall Creek. MD 260's heading shifts from southeast to east where it meets Mount Harmony Road at a trumpet interchange in the hamlet of Paris. A few houses and small businesses are situated within this interchange. Mount Harmony Road, which has a bridge over eastbound MD 260 and the ramp from Mount Harmony Road to westbound MD 260, is unsigned MD 260D within the interchange. East of the interchange at Lafayette Drive, the state highway becomes a four-lane
divided highway, and the
median becomes wide and forested just east of the Boyds Turn Road-Horace Ward Road intersection. The median narrows as MD 260 enters the town of Chesapeake Beach and ends as the highway transitions to a two-lane road with a
center left-turn lane at G Street. The highway continues four blocks to its eastern terminus at MD 261 (Bayside Road) just west of the
Chesapeake Bay shoreline and several blocks north of Fishing Creek and the
Chesapeake Beach Railway Station. The section of the median between the Harrison Boulevard-Limerick Lane intersection and the G Street-Cox Road intersection is decorated with many
Christmas light displays by the Town of Chesapeake Beach during the holiday season. ==History==