MD 725 begins at an intersection with Brown Station Road on the west side of Upper Marlboro. Old Marlboro Pike continues west as a county highway. The state highway heads east as a two-lane undivided road. After passing John Rogers Boulevard, MD 725 crosses Federal Spring Branch and enters the town limits of Upper Marlboro. The state highway curves south, then turns east at the intersection with Old Crain Highway, where the highway's name changes to Main Street. MD 725 heads into the downtown area, where the highway meets the northern end of
MD 717 (Water Street) and passes many county buildings, including the county courthouse. The state highway passes Governor Oden Bowie Drive, where the highway's name changes to Marlboro Pike, and heads northeast out of the downtown area. MD 725 leaves the town limits by crossing the Western Branch of the
Patuxent River and immediately meets the eastern end of
MD 202 (Largo Road). The state highway passes several industrial buildings that cluster around the road's at-grade crossing of
CSX's
Popes Creek Subdivision railroad line. MD 725 reaches its eastern terminus at a cluster of restaurants surrounding the intersection with US 301 (Robert Crain Highway). Marlboro Pike continues east as a county highway. MD 725 is a part of the
National Highway System as a principal arterial from MD 202 to US 301. ==History==