Galerekwe Mase Manopole is a South African politician who has served as the Northern Cape MEC for Social Development, Youth, Women and People Living with Disabilities since January 2026. She was the MEC for Health from May 2019 to June 2020 and the MEC for Land Reform, Agriculture and Nature Conservation and Environmental Affairs from June 2020 until January 2026. She joined the Northern Cape Provincial Legislature in October 2017. From May 2014 to October 2017, she was a permanent delegate to the National Council of Provinces, representing the Northern Cape. Manopole is a member of the African National Congress.