•
Rufa Mae Quinto as Boobita Rose: A hardworking, physically gifted girl and breadwinner of a dysfunctional unappreciative family. •
Antonio Aquitania as Randy •
Gina Pareño as Lupe: Boobita's mother who is a nymphomaniac and self-pitying mess. Pareño is known for easily switching from drama to comedy when the situation calls for it. •
John Lapus as Bogs: Boobita's drug-addicted womanizer brother who gets girls pregnant. He has love scenes with no less than three
Viva Hot Babes, namely Andrea del Rosario, Ella V. and Gwen Garci. Lapus is a confirmed gay, but he said he got “turned on” with Ella V. •
Sunshine Dizon as Brigitte: Boobita's alcoholic sister, a role Dizon said she never thought she’d play. She stated, "[The role is] So opposite of the real me that’s why it’s very challenging.” •
Phytos Kyriacou as Boogie •
Tita Swarding as Lolo Benito: the family’s drunkard grandfather, a ‘straight’ role, contrary to Swarding's real gay self. •
Rudy Hatfield as Mark • Jannica Pareno as Mark's wife •
Kier Legaspi as Lupe's boyfriend •
Bernard Bonnin as Bogart: Lupe's husband who comes back to her only when he runs out of money. Otherwise, he’s with different women. Bonnin expressed “First time I’m doing this kind of comedy. I like it.” •
Charlie Davao as Senator •
Chinggoy Alonso as Boss •
Raquel Montessa as Boss' wife • Ralion Alonso as Boss' son • Earl Ignacio as Teacher • Lui Manansala as Principal
Singers •
Bituin Escalante (performed
"Lupa") •
Blakdyak (performed ''"Don't Do That, Joey"'') • Salbakuta (performed
"Long Distance") •
Ogie Alcasid (performed
"Huwag Ka Lang Mawawala") •
Lani Misalucha (performed
"Tila") •
Regine Velasquez (performed
"Saan Ako Nagkamali") •
Mark Bautista (performed ''"Kapag Ako'y Kailangan"'') •
Sarah Geronimo (performed
"Ibulong sa Hangin" and
"You Are My Song") •
Karylle (performed
"Breaking My Heart") •
Kyla (performed
"Maghihintay Lamang") •
Anna Fegi (performed
"Wala Ka Na") •
Nina (performed
"What If") •
Ely Buendia (performed
"Keeper") •
Martin Nievera (performed
"You Are My Song")
Cameo appearances •
Andrea del Rosario •
Bobby Andrews • Kristine Jaca •
Gwen Garci ==Soundtrack==