The Mater Dei Prep Seraphs competed in Division B Central of the
Shore Conference, an athletic conference comprised of public and private high schools in
Monmouth and Ocean counties along the
Jersey Shore. The conference operates under the jurisdiction of the
New Jersey State Interscholastic Athletic Association (NJSIAA). With 212 students in grades 10-12, the school was classified by the NJSIAA for the 2019–20 school year as Non-Public B for most athletic competition purposes, which included schools with an enrollment of 37 to 366 students in that grade range (equivalent to Group I for public schools). The school was classified by the NJSIAA as Non-Public Group III for football for 2018–2020. The school participates as the host school / lead agency for joint cooperative football team with
Ranney School. The co-op program operates under an agreement scheduled to expire at the end of the 2023–24 school year. The boys track team won the Non-Public Group B spring / outdoor track state championship in 1967, 1973, 1999, 2000, 2006 and 2017-2019. The program has won 10 state titles, which is tied for eighth-most among all schools in New Jersey In June 2018, the team set numerous school records and took home both a sectional title and their second consecutive Non-Public B group state title. The baseball team won the Non-Public B South championship in 1967, 1968 and 1970. The girls cross country team won the Group I state championship in 1976, 1977, 1987, 1991 and 1992, and won the Non-Public Group B state title in 1982-1985. The nine state championships won by the program are ranked fifth in New Jersey. The girls basketball team won the Group I state championship in 1980 (defeating
Benedictine Academy in the tournament final) and won the Non-Public Group B title in 1990 (vs.
Immaculate Conception High School of Montclair). The team won the 1980 Group I title with a 64-52 win in the finals against Benedictine Academy. The boys soccer team won the Non-Public Group B state championship in 1981 and 1983, against runner-up
Eastern Christian High School both years in the finals of the tournament. The 1983 team finished the season with a 16-4 record after defeating Eastern Christian by a score of 3-1 at
Mercer County Park in the Parochial B finals. The boys tennis team won the Non-Public B/C state championship in 1981, defeating
Oratory Preparatory School in the final match of the tournament. The girls spring track team was the Group I state champion in 1981 and won the Non-Public Group B title in 1982, 1983 and 2000. The boys track team won the indoor track state championship in Non-Public Group B in 1981. The girls tennis team won the Non-Public B state championship in 1982, defeating
Pope John XXIII Regional High School 5-0 in the tournament final. The boys cross country running team won the Non-Public Group B state championship in 1984, 1985, 1997, 1999, 2007 and 2017. The program's seven state titles are tied for tenth-most in the state. The softball team won the Group II state championship in 2008, defeating
Montclair Kimberley Academy in the finals of the tournament. The football team won the Non-Public Group II state sectional championship in 2016, winning by a score of 26-20 in the tournament final against
Holy Spirit High School on a touchdown scored on a
hook and lateral play with 11 seconds left in the game. The boys track team won the indoor relay state championship in Non-Public Group B in 2018 and 2019. The girls team won the Group II title in 2013, In 2018, the boys' winter / indoor track team finished their season with the program's first state indoor relay championship title and was runner-up in the Non-Public B state championships. == Notable alumni ==