In the early 1990s, Moeti worked for the Botswana Ministry of Health. She then joined
UNAIDS, rising to the position of Team Leader of the Africa and Middle East Desk, based in Geneva, from 1997 until 1999. She also served as the Regional Health Advisor for
UNICEF's Regional Office for East and Southern Africa. In 1999, Moeti joined the WHO Regional Office in Africa, working on
HIV/AIDS. She was appointed as Assistant Regional Director, serving in that capacity from 2008 until 2011. She also served as the Director of Noncommunicable Diseases at the regional office. From 2005 until 2007, she served as the WHO Country Representative in
Malawi. At the time of her appointment to her current position, she was the
Coordinator of the Inter-Country Support Team for the South and East African countries of WHO African Region. She assumed office on 1 February 2015, to serve a renewable five-year term. This followed the endorsement of the health ministers of the 47 member countries in the Africa Region, at their meeting in
Cotonou, Benin, in November 2014. She replaced
Luis Gomes Sambo of Angola, who served as the Director of AFRO from 2005 until 2015. She was reelected for a second term in 2019. She was succeeded in 2025 by
Mohamed Yakub Janabi of Tanzania. ==Other activities==