Jorgenson had an active
2022 Tour de France and was involved in several breakaways including on stages 10 and 16. Late in stage 16, he was in the process of chasing down the lead rider
Hugo Houle when he crashed while rounding a sharp corner. Despite the crash, he was still able to finish fourth on the stage. In the
2023 Tour de France, Jorgenson was involved in a 14-man breakaway on stage 9. With around 47 km remaining of the stage, he went clear from the group, leading the stage for most of the climb up the
Puy de Dôme. However, within the final 500 metres, he was passed by
Michael Woods and others, ultimately finishing fourth. He had to abandon the Tour a few days later, however, due to injuries suffered during a crash. Jorgensen won the
2024 Paris–Nice, becoming the first American to win the race since
Floyd Landis in 2006. His win was in significant part due to him being in a three-man breakaway on Stage 6, where they finished more than 50 seconds ahead of most of the race favorites. Jorgensen placed second in the 2024 Criterium du Dauphine. He started the final stage over a minute behind Primoz Roglic and attacked on the final climb. With Roglic unable to hold his wheel, Jorgensen and Carlos Rodriguez gained 56 seconds on the leader. With time bonuses, Jorgensen finished the race 8 seconds behind Roglic. Jorgenson also rode in the
2024 Tour de France, in which he finished 8th in the general classification. ==Major results==