In 2006, Molinari turned professional. In 2007 he won the
Club Colombia Masters and the
Tusker Kenya Open on Europe's developmental
Challenge Tour. The two victories and his consistent play led to a 16th-place finish on the season-long money list. That success enabled him to play on the top level
European Tour during the 2008 season. Molinari's play was uneven during that season due to a wrist injury, and he was unable to retain his playing privileges in 2009. Molinari returned to the Challenge Tour in 2009, where he was again successful, earning his third professional title at the
Piemonte Open in May, in his home town of Turin. He also won the
Kazakhstan Open in September and the
Italian Federation Cup in October. He also came 2nd in the
Club Colombia Masters, the
Scottish Hydro Challenge, the
Trophée du Golf de Genève and the
ECCO Tour Championship. On 29 November 2009, Molinari partnered with his younger brother Francesco to lead Italy to their first
World Cup win at the Omega Mission Hills World Cup outside Shanghai, China. Edoardo leapt joyously around the 18th green after sinking the winning putt. This was the first win in the event by brothers and the first Italian victory in the event, generating significant coverage in the Molinari brothers' homeland. During 2009, Molinari's
Official World Golf Ranking rose from 753 to 48. On 29 March 2010, Molinari earned his best finish on the U.S.
PGA Tour, finishing second by two shots to South African
Ernie Els at the
Arnold Palmer Invitational and earning his then largest check of $528,000US. Molinari holed a 50-foot putt on the 17th hole of the final round that was selected as "Shot of the Day" by NBC, the US network covering the tournament. On 11 July 2010, Molinari won his first European Tour tournament, claiming the
Barclays Scottish Open at
Loch Lomond by three strokes over
Darren Clarke.
Francesco Molinari played alongside his brother and Clarke in the final threesome. Following Franceso's win in the 2006 Italian Open, Edoardo's victory in Scotland made the pair the third brothers to win on the European Tour after
Seve and
Manuel Ballesteros and
Antonio and
Germán Garrido. On 29 August 2010, Molinari won his second European Tour title, the
Johnnie Walker Championship at Gleneagles, by one stroke from Australian
Brett Rumford, after birdieing the final three holes. Molinari's brother Francesco once again was paired with the eventual champion in the final round. Shortly afterwards, European
Ryder Cup captain
Colin Montgomerie named Molinari as one of his three "wild card" selections for the
2010 matches at
Celtic Manor in
Wales, along with
Pádraig Harrington and
Luke Donald. Molinari's brother Francesco also earned a place on the European team through the points list. The Molinaris were the first brothers to compete together in a Ryder Cup side since
Bernard and
Geoffrey Hunt played for the Great Britain and Ireland side in
1963. Molinari's successful 2010 campaign saw him rise to a career-high of fourteenth in the
Official World Golf Ranking. Molinari finished the 2010 season ranked 11th on the Race to Dubai, formerly known as the European Tour Order of Merit. He finished the year ranked 18th in the world. Molinari spent the first half of the year racking up middle of the pack finishes, with an 11th-place finish at Augusta as his lone highlight. He noted that "I know my progress this season has not been so good, but the time that I have spent on the PGA Tour in America has been a positive experience" in an essay he wrote as a special Open Championship correspondent for
The Independent. Molinari finished the 2011 season ranked 46 on the Race to Dubai with earnings of 686,391 Euros from 21 events. A quarter of his earnings came through his season best finish of fifth at the
Barclays Singapore Open. Molinari fell out of the world ranking top 50 by the end of the season. An old injury to Molinari's left wrist led to tendonitis and ultimately required tendon surgery in June. His 2012 campaign was interrupted by a three-month layoff with Molinari returning to action at the
BMW Italian Open in September. He achieved only one top-10 finish on the European Tour, sixth at the
Trophée Hassan II, and qualified for only one major, the
Masters Tournament. Molinari dropped to 86th on the 2012
Race to Dubai with earnings of 280,976 Euros from 17 events. He fell out of the top 200 of the Official World Golf Ranking, as well. Molinari set a goal of fully rehabilitating his left wrist for the 2013 season. Molinari started the
2013 European Tour season with a series of missed cuts, but on 24 March, he obtained a strong second place at the
Maybank Malaysian Open. The prize won (233,604 Euros) allowed him to enter the Race to Dubai ranked 29th. Scoring a solid 68 (4 under par) in the final round, Molinari finished the
Open de España tied for 27th position. At the
2013 BMW PGA Championship, won by his countrymate
Matteo Manassero, Molinari finished T19 with two consecutive birdies on the 71st and 72nd holes. He had to withdraw from the
BMW International Open and the
Irish Open for persistent pain in his left thumb. In November 2013, after recovering from a new surgery, Molinari began his
2014 European Tour comeback campaign in South Africa where he ended T52 at the
South African Open Championship. He made his first cut since the
BMW PGA Championship played in May 2013. At the
Abu Dhabi HSBC Golf Championship on 19 January 2014, he finished T28 after four consecutive under-par rounds (70-71-71-71) which earned him a final score of −5. He earned him his first top-10 of the season at the
Omega Dubai Desert Classic (T9) and moved to 64th place in the
Race to Dubai rankings. After that, he had a good period of form with three consecutive cuts made at the
Joburg Open (T37) and
Tshwane Open (T10) in South Africa and at the
Trophée Hassan II (T25) in Morocco, respectively. During the next following months he played in a very consistent fashion, with multiple cuts made in a row, a period culminating in a second place at the
Irish Open behind
Mikko Ilonen of Finland and in his best finish so far (T7) at
The Open Championship. Another solid display at the
Wales Open, where he finished T4, gave him a total of 787.855 Euros. He ended the Race to Dubai in 40th place and won a total of €915,070, the second best
European Tour final position and prize of his career to date. Molinari started reasonably well his
2015 European Tour campaign with 6 cuts made out of 8 participations, with the highest position he occupied represented by his T15 finish at the
Tshwane Open; however a slump of form in the final part of the season, with eight consecutive missed cuts, cost him his European Tour card. In November 2015 he promptly regained his European Tour membership with a 24th place at the
2015 European Tour Qualifying School. His
2016 European Tour campaign was not particularly brilliant (only 13 cuts made out of 27 participations) and at the end of season he found himself in 148th position (prize won 132,580 Euros) in the
Race to Dubai rankings, losing again his European Tour card. For a second consecutive year, he was able to promptly regain his European Tour membership with a T2 place at the
2016 European Tour Qualifying School. Molinari is working with Irish caddie Colin Byrne, who has earned 20 wins with other golfers such as South African major champion
Retief Goosen. == Personal life ==