Club Brugge De Cuyper began his career at the youth academy of
Club Brugge. On 20 February 2020, De Cuyper made his professional debut for Brugge against
Manchester United in the first-leg of the
UEFA Europa League Round of 32. He started and played 73 minutes as Club Brugge drew 1–1. De Cuyper was then a starter again for Brugge in the second leg of the tie and played the whole match as Brugge fell 0–5. On 30 August 2020, De Cuyper made his debut for
Club NXT, Brugge's reserve team, in
Belgian First Division B. He came on as a 64th minute substitute as Brugge were defeated 2–2. On 4 February 2022, Club Brugge announced that they had extended de Cuyper's contract through 2025.
Westerlo (loan) On 2 August 2021, he joined
Westerlo on loan for the 2021–22 season. The loan was extended for the 2022–23 season.
Brighton & Hove Albion in 2026. On 5 July 2025, De Cuyper transferred to
Premier League club
Brighton & Hove Albion for an undisclosed transfer fee, signing a five-year contract. On 16 August, he made his debut for the club in a 1–1 draw against
Fulham in the league. ==International career==