Wiley served in the Civil Division of the
U.S. Attorney Office for the Southern District of New York. In 2013, Wiley was mentioned as a potential president of the
NAACP, but the post went instead to
Cornell William Brooks. Before being appointed counsel to Mayor
Bill de Blasio in 2014, she worked for the
NAACP Legal Defense and Educational Fund, the
American Civil Liberties Union and the
Open Society Institute. She also founded and served as president of the Center for Social Inclusion, a national policy strategy organization dedicated to dismantling
structural racism. Wiley has taught at
The New School, where she founded the Digital Equity Laboratory, and appeared on
MSNBC as a political and legal analyst. In November 2023, Wiley was named the District of Columbia School of Law Foundation's Joseph L. Rauh Jr. Chair of Civil and Human Rights.
2021 New York City mayoral campaign Wiley ran in the
Democratic primary for
mayor of New York City in 2021. and former presidential candidates
Julian Castro and
Elizabeth Warren, as well as Local 1199 of the Service Employees International Union, the largest union in New York City. She was also endorsed by
The Strokes, whose song "Starting Again" was included in a campaign advertisement. The band also played a
fundraising concert at
Irving Plaza on June 12, 2021. Wiley placed third in the Democratic primary, behind
Eric Adams (who was later elected in the general election) and
Kathryn Garcia.
Leadership Conference on Civil and Human Rights In March 2022, the
Leadership Conference on Civil and Human Rights announced Wiley's appointment as its president and CEO, and of its sister group, The Leadership Conference Education Fund, effective May 2. In 2023, she represented the Leadership Conference at a meeting hosted by Vice President
Kamala Harris with labor and rights groups to discuss threats from
artificial intelligence (AI), and as a panelist at the
U.S. Senate's inaugural AI Insight Forum, hosted by majority leader
Chuck Schumer. Wiley also attended White House meetings during the Biden administration, alongside other civil rights leaders, to advocate for stronger voting rights and more economic opportunities for the Black community. In 2025, she endorsed
Zohran Mamdani's campaign for
Mayor of New York City in the
2025 mayoral Democratic primary. ==Personal life==