Mayflower station was first announced as part of the 22-station Thomson Line (TSL) on 29 August 2012. In October 2013, the contract for the design and construction of Mayflower station was awarded to
Gammon Construction Limited Singapore Branch at . The station's construction began in 2014, with a scheduled completion date of 2020. On 15 August 2014, the
Land Transport Authority (LTA) announced that the TSL would merge with the Eastern Region Line to form the Thomson–East Coast Line (TEL). Mayflower station, along the proposed line, would be constructed as part of TEL2, consisting of six stations between
Springleaf and
Caldecott. Prime Minister
Lee Hsien Loong inaugurated the station's groundbreaking ceremony on 6 September. Since the station is directly underneath Ang Mo Kio Avenue 4, its construction required traffic to be diverted in 15 phases. The sloping topography created height differences, which made it difficult to position the working platforms for the boring rigs and cranes to be used for the construction. Barriers were installed to minimise noise pollution, with workers draping noise curtains on heavy machinery. With restrictions imposed on construction due to the
COVID-19 pandemic, the TEL2 completion date was pushed to 2021. On 14 December 2020, it was further announced that the opening of TEL2 was delayed to the third quarter of 2021 so the rail system software for the line could be reviewed. As announced during a visit by Transport Minister
S. Iswaran at Caldecott station on 30 June 2021, the station began operations on 28 August 2021. ==Station details==