It flows roughly northwards from its source in the small Maynskoe Lake, located in the northern part of the Parapol Valley, in the
Penzhinsky Range of the
Koryak Highlands. The river passes then through sparsely populated areas of the
forest-tundra subzone of Chukotka. Finally it joins the right bank of the Anadyr. The Mayn meets the Anadyr at Ust-Mayn in the mid-lower stretch of its course, in an area of wetlands and small lakes, about further upstream from the confluence of the Anadyr and the
Belaya. All these rivers are frozen for about eight to nine months in a year between mid-October and the end of May. There were ancient settlements in the Mayn basin. In present times
Vayegi town lies in the Mayn's middle course and
Ust-Mayn village at the confluence of the rivers Mayn and Anadyr. Administratively the whole basin of the Mayn and its tributaries belong to the Chukotka Autonomous Okrug. ==Flora and fauna==