In February 2020, the band announced "The Van Tour 2020", a 25th-anniversary tour where the band would perform in all of the same cities as the band had twenty-five years prior in their first North American tour, only in larger venues. While the tour was originally scheduled to run in April and May 2020, the
COVID-19 pandemic forced the band to delay the tour to October and December of the same year. In May 2020, the band announced that they had indefinitely delayed the album, while the band figures out how to promote and sell the album after the pandemic. While the initial delay was due to the pandemic and the band's inability to tour in support of it, Grohl later decided to release it during the pandemic anyhow, upon realizing its ability to be heard and lift people's spirits outweighed their desire to tour in support of it. Anticipation remained high for the album;
Kerrang! placed the album atop of their "15 Albums Still to Look Forward to in 2020" list. Promotions picked back up again in November of the same year. The band announced they would perform on the November 7 episode of
Saturday Night Live. Treading up to the performance, they started teasing new music snippets of a song on their social media platforms. On November 7, the band released the first single, "Shame Shame". On January 1, 2021, the band released the second single of the album, "No Son of Mine". On January 14, the band released the third single, "Waiting on a War". In the United States,
Medicine at Midnight debuted at number three on the
Billboard 200 album chart which was earned by 70,000 equivalent album units, 64,000 of which were album sales, making it the top-selling album of the week. ==Critical reception==