Shyu was an undergraduate at
Feng Chia University in Taiwan, where she earned a degree in traffic and transportation engineering and management in 1986. She went to
Purdue University for graduate study, completing a Ph.D. in electrical and computer engineering in 1999. Along the way, she also earned three master's degrees, in computer science in 1992, in electrical engineering in 1995, and in restaurant, hotel, institutional and tourism management in 1997. Her doctoral dissertation,
A probabilistic network-based mechanism for multimedia database searching and data warehousing, was supervised by
Rangasami L. Kashyap. She joined the
University of Miami as an assistant professor in 2000, and was promoted to associate professor in 2005 and to full professor in 2013. She moved to the University of Missouri–Kansas City in 2022. ==Recognition==