Melanie was first found by her half-brother
Max Brady, and she was baffled when she found out that she had a brother living in Salem. Melanie followed Max back to Salem, and eventually moved to town. Trent, who is generally hated by all in town, was murdered; Melanie was the main suspect. She confesses to having a serious fight with him the night of the murder but also says she maintained her cool and wouldn't have even attempted to kill him. It was later revealed that
Nick Fallon, a friend of hers (he was in love with Melanie, but she wasn't interested in him) had killed Trent, due to problems with an alternative fuel project at the university. Melanie inherited her father's goods. Initially Melanie had encouraged Nick to continue his work with the fuel project so they could sell it in order to attain money and not turn himself in for the murder; however, when Nick became too obsessed with Melanie and even proposed to her at one stage, she turned him in herself to avoid him. Nick was sent to jail. He signed over his share of the fuel project to Melanie, allowing her to get a job at Titan, and she developed a crush on
Philip Kiriakis, her boss at the time; however, she casually was dating Nathan Horton https://en.wikipedia.org/wiki/List_of_Days_of_Our_Lives_characters_introduced_in_the_2000s#Nathan_Horton. She had a rivalry with
Stephanie Johnson, Phillip's then girlfriend (who had previously dated Max, and Melanie hated her then too). Nathan and Melanie both worked at the Salem Hospital together, and he developed deep feelings for her. Melanie chose to engage Phillip, unaware of Nathan's true feelings. Melanie is both elated and confused to learn that
Daniel Jonas (a doctor at the hospital) is her father, and later, it is revealed that
Carly Manning is her mother (she was conceived during an affair they had many years ago) and that Trent isn't even blood-related to her. Melanie developed a deep friendship with
Maggie Horton, whom she viewed as a mother. She became instantly well acquainted to her new parents. Nathan and Melanie kissed and fell in love during her engagement, however they were never physical. They planned to run away before her marriage to Phillip, but she stayed true to her commitments. On the day of her wedding, her mother's stalker (who was seeking revenge on Carly for killing her husband, who was Vivian's nephew, in self-defense)
Vivian Alamain (
Louise Sorel) (who had befriended and manipulated Melanie to kill her to get revenge on Carly) poisoned her comb. She was fine, and Vivian's plans to allow Carly to watch her daughter die failed. However, Carly shoots Vivian, but Melanie jumps in the way (protecting Vivian, whom she assumed was on her side). Melanie slipped into a brief coma. Vivian tries to kill Melanie in the hospital, and Melanie tells Vivian her life story, which touches Vivian who relents. Melanie and Phillip are married and Vivian shifts her attention from Melanie to Carly. When Phillip sees Melanie and Nathan together (they were not physical, just passionately holding each other), he goes to his former flame and Daniel's fiancée,
Chloe Lane, and they have sex. It was later revealed that Chloe was pregnant. She goes through her pregnancy with the knowledge that the baby has two possible fathers. After the child is born, Phillip is revealed as the father. Melanie left him and ended their marriage, despite briefly tricking him into thinking she loved him to take away his and Chloe's baby, Parker, with encouragement from his own mother,
Kate DiMera who despised Chloe. She is pregnant with Phillip's child, but loses the baby during an altercation with Stephanie. She briefly dates Nathan, however he leaves, thinking they can never be together due to the hassle already caused. Melanie dates Dario,
Rafe Hernandez's brother, who leaves town, devastating Melanie. Melanie kisses her best friend
Abigail Deveraux's boyfriend,
Chad DiMera. The two have a fling which upsets Abigail. Later after Abigail has moved on, Gabi Hernandez develops feelings for Chad as well. In order to get Chad all to herself Gabi hires a man to kidnap Melanie, who takes her down into the DiMera tunnels causing an explosion that almost killed Jack Deveraux, because of the experience Melanie leaves town in 2012, to join her mother Carly in Europe. In 2014, Melanie returns to Salem after getting into some trouble in Europe. She develops a relationship with Brady Black and the two get engaged, but when Theresa Donovan threatens Melanie to not allow Brady to see his son Tate unless she leaves town, she breaks off the engagement and exits the show once again in 2015. She comes back for a quick visit in January 2016, for Daniel's funeral. ==Reception==